What Cagrilintide is
Cagrilintide is a 37-residue analog of amylin, the peptide hormone co-secreted with insulin by pancreatic beta cells. It keeps amylin's ring structure, a disulfide bond between cysteines 2 and 7, and its amidated C-terminus, but carries a 20-carbon fatty diacid attached to the N-terminal lysine through a γ-glutamate linker, plus several residue substitutions that reduce amylin's tendency to aggregate. It is designed as a long-acting agonist of the amylin receptors and the calcitonin receptor, which share the calcitonin receptor protein.
Cagrilintide Labs supplies it as a lyophilized powder in 5 mg vials. Each lot is tested by an independent laboratory for HPLC-UV purity, LC-MS identity and net content, and the certificate is published here before sale through Klow.bio.
Structure
Lys1 carries an eicosanedioic acid (C20 diacid) linked through γ-glutamate; the Cys2–Cys7 disulfide forms an N-terminal ring; and Pro37 is amidated. The lipid chain makes the molecule strongly hydrophobic, so it elutes late on reversed-phase HPLC, much like other fatty-acid-modified peptides.
complete Cagrilintide specifications.
Storage and handling
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. Lyophilized material absorbs moisture from the air, and absorbed moisture restarts the reactions that drying slows, so keep vials sealed until needed. Storage and stability guide.